Journal of Sleep Reseach, February 2020<\/strong> Abstract<\/strong> Reduced structural connectivity in Insomnia Disorder Journal of Sleep Reseach, February 2020Kira V Jespersen, Angus Stevner, Henrique Fernandes, Stine D S\u00f8rensen, Eus Van Someren, Morten…<\/p>\n
Kira V Jespersen, Angus Stevner, Henrique Fernandes, Stine D S\u00f8rensen, Eus Van Someren, Morten Kringelbach, Peter Vuust<\/p>\n\n\n\n
Insomnia Disorder is the most prevalent sleep disorder, and it involves both sleep difficulties and daytime complaints. The neural underpinnings of Insomnia Disorder are poorly understood. Several existing neuroimaging studies focused on local measures and specific regions of interests, which makes it difficult to judge their whole\u2010brain significance. We therefore here applied a data\u2010driven approach to assess differences in whole\u2010brain structural connectivity between adults with Insomnia Disorder and matched controls without sleep complaints. We used diffusion tensor imaging and probabilistic tractography to assess whole\u2010brain structural connectivity, and examined group differences using network\u2010based statistics. The results revealed a significant difference in the structural connectivity of the two groups (p<\/em>\u00a0=\u00a0.014). Participants with Insomnia Disorder showed reduced connectivity in a sub\u2010network that included mainly fronto\u2010subcortical connections with the insula as a key region. By taking a whole\u2010brain network perspective, our study enables the integration of previous inconsistent findings. Our results reveal that reduced structural connectivity of the left insula and the connections between frontal and subcortical regions are central neurobiological features of Insomnia Disorder. The importance of these areas for interoception, emotional processing, stress responses and the generation of slow\u2010wave sleep may help guide the development of neurobiology\u2010based models of the prevalent condition of Insomnia Disorder.<\/p>\n","protected":false},"excerpt":{"rendered":"